LY 2812223

Research use only, not for human use.

A highly potent, functionally selective mGlu2 receptor agonist with EC50 of 13.6 nM in GTPγS functional binding assay.

A highly potent, functionally selective mGlu2 receptor agonist with EC50 of 13.6 nM in GTPγS functional binding assay; displays little to no affinity for mGlu1, mGlu4, mGlu5 or mGlu7 receptors; fully displaces the mGlu2/3 agonist radioligand [3H]LY459477 with Ki of 118 nM, inhibits forskolin-stimulated cAMP with EC50 of 16.1 nM; displays near maximal agonist responses at the mGlu2 receptor across all assay formats, while shows no functional agonist activity at the mGlu3 receptor except in the cAMP assay. Alzheimer Disease Phase 2 Clinical.

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LY2812223 | LY-2812223

GPCR/G Protein

mGluR

mGluR

Neurological Disease

Alzheimer Disease

1311385-20-2

835.828

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>98% (HPLC)

In Vitro:?H2O : 50 mg/mL (175.88 mM)

[H][C@]12[C@]([C@H]2C(O)=O)([H])[C@@](C(O)=O)(N)C[C@H]1SC3=NNC=N3

(1R,2S,4R,5R,6R)-2-amino-4-(1H-1,2,4-triazol-3-ylsulfanyl)bicyclo[3.1.0]hexane-2,6-dicarboxylic acid

(-20℃)

With Ice Pack

≥ 2 years